Causes
- soulsunleashed
- July 12, 2025
Depression, or Major Depressive Disorder (MDD), is one of the world’s most disabling health conditions. It affects how people think, feel, and function—and is far more than simply “feeling sad.”
According to the World Health Organization, depression affects over 280 million people globally, with rising rates among young adults. WHO, 2024
FREQUENTLY ASKED QUESTIONS
Is depression purely genetic?
No. Genetics play a significant role, but life events, stress, and environment often determine whether someone develops depression. Many people with genetic risk factors never become depressed.
Can diet really impact depression?
Yes! Diets rich in whole foods, healthy fats, and fiber have been linked to lower depression rates, while high-sugar, processed diets increase risk.
How does inflammation relate to depression?
Recent research shows chronic inflammation may disrupt brain function and mood, making inflammation a possible cause—and target for new treatments.
Can lack of sleep cause depression?
Absolutely. Poor sleep increases the risk of depression, and depression often disrupts sleep. Improving sleep hygiene is critical for mental health.
KEY TERMS
Genetics
- Depression often runs in families.
- 40-50% of the risk is heritable.
- Researchers have identified over 100 genetic variants linked to depression risk. NIH, 2024
Brain Chemistry & Neurotransmitters
- serotonin, dopamine, and norepinephrine have long been implicated.
- New findings suggest brain connectivity and neural circuits may be more critical than single chemicals.
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Imaging studies reveal abnormal activity in areas regulating emotion, memory, and motivation.
Hormonal Changes
- Pregnancy & postpartum period
- Menopause
- Thyroid dysfunction
Inflammation & Immune System
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Exciting new research links chronic inflammation to depression:
- People with depression often have higher levels of pro-inflammatory cytokines.
- Chronic inflammation may disrupt neurotransmitter production.
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Some researchers call depression an “inflammatory disease of the brain.”
